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Do you mean comedy? I find that it alleviates my depression, but that it does not end it. Of course, though, I have dysthymia, which means that my life is pretty normal except for that constant tiredness and hopelessness at the back of my mind. Wits are good cure for bad mood in general.

Depressed people however, I would say, are more sarcastic than witty. Wits end depression.